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I love trying new serums, and comparing peptide-packed options is one of my favorite beauty pastimes. Right now I’m looking at a varied lineup: the XY Professional EGF Peptides Serum (with epidermal growth factor and ginseng stem‑cell ampoule), Korea Microneedling Academy supplies for at-home/professional skin needling support, The Ordinary Multi‑Peptide + Copper Peptides 1% anti‑aging serum, and Le Mieux Collagen Peptide Serum with hyaluronic acid. Each promises to boost firmness, texture, or hydration in slightly different ways, so I’m excited to see which ingredients and formats actually deliver noticeable results.

Peptide and growth-factor topical treatments have evolved from wound‑healing research and clinical dermatology into mainstream skincare over the past few decades; copper peptides, EGF, collagen‑supporting peptides, and plant stem‑cell extracts all stem from that science-first shift. Owning these kinds of products can help support your skin’s natural repair and collagen production, improve elasticity and fine lines, and enhance hydration and overall tone—especially when combined with treatments like microneedling that increase absorption. In the article, I’ll take a closer look at each item, comparing ingredients, texture, claimed benefits, and which skin types or routines they’re best suited for so you can decide which one fits your needs.

XY Professional EGF Peptide Face Serum — Ginseng Stem Cell Ampoule (Korea)

I recently tried the XY Professional EGF Peptides Serum For Face Skin BOOST Epidermal Growth Factor Ginseng stemcell Ampoule, KOREA Microneedling academy supplies as part of my microneedling aftercare routine for acne scar repair. Below I share my hands-on review — what it’s best for, why I like it, a clear overview of its purpose and key features, an assessment of overall quality, and a balanced list of pros and cons based on my experience.

primary use

Intended application

I use this serum primarily as a targeted aftercare product following microneedling sessions, focusing on acne scar repair. The serum is formulated to support skin renewal and address texture irregularities, so it’s meant to be applied to the face (and scalp if desired) to promote improved tone and elasticity. For me, the main goal was to aid recovery, reduce the appearance of depressed acne scars, and help skin look smoother and more radiant between treatments.

How I used it

I applied a small amount after my microneedling sessions once the skin had calmed (following the clinic’s guidance to wait until the immediate redness subsided). On non-treatment days I used the serum in the evening after cleansing and before moisturizing. I always do a patch test first and apply a thin layer to avoid overloading freshly treated skin.

why we like this product

Standout benefits I noticed

I like this serum because it combines several powerful ingredients that are commonly recommended for wound-healing and skin texture improvement. The inclusion of EGF (Epidermal Growth Factor) and a Peptide Complex felt particularly suited to my microneedling aftercare needs — these ingredients are intended to support skin renewal. The extra boost from niacinamide helped even out skin tone and calm redness, while copper peptides contributed to a firmer, more resilient feel over time.

Sensory experience and packaging

The texture is lightweight and absorbs quickly, which I appreciated when layering after microneedling. The ampoule-style packaging (typical of Korean skincare serums) feels premium and hygienic. I liked that it’s marketed for both face and scalp — I used a tiny amount on a thinning patch I’m treating and found the formula not too heavy.

an overview of the products purpose and key features

Product purpose

The XY Professional EGF Peptides Serum is designed as a concentrated treatment to boost skin renewal, improve texture, and enhance radiance. It’s aimed at users who want to support recovery post-procedure (like microneedling) and those looking to address signs of aging or mature-skin concerns. Because it’s formulated for both the face and scalp, it’s versatile for several targeted applications.

Key features and ingredients

• EGF (Epidermal Growth Factor): included to support cellular turnover and renewal, which can be beneficial after microneedling when the skin’s repair processes are activated.
• Peptide Complex: a blend meant to promote firmness and the appearance of smoother skin.
• Niacinamide: helps even skin tone and can reduce the look of post-inflammatory discoloration common with acne scarring.
• Copper Peptides: associated with improved elasticity and smoothness, a helpful addition for scarred or mature skin.
• Ginseng Stem Cell Extract: adds antioxidant support and a “special care” component aimed at improving the appearance of mature or stressed skin.
• Korean skincare formulation: the serum pulls from advanced cosmetic science trends in Korean beauty, emphasizing both efficacy and sensory experience.

These features together make it a targeted post-procedure and corrective product rather than a basic daily moisturizer.

overall quality

Formulation and performance

From a formulation standpoint, the serum feels well-balanced — it’s potent without being greasy. Over several weeks of consistent use alongside my microneedling sessions, I noticed gradual improvements in texture and a softer appearance around depressed acne scars. My skin also looked slightly more radiant and even-toned, which I attribute to the niacinamide and peptide blend. The ampoule delivery keeps the active ingredients fresh and concentrated.

Safety and tolerability

I found the serum quite tolerable, but I still recommend a patch test, especially after procedures like microneedling. I waited until initial sensitivity decreased before using it directly on freshly treated areas. If you have very reactive or eczema-prone skin, introduce the product slowly. The formula contains multiple actives, so layering it correctly (thin layer, then barrier-supporting moisturizer) helps prevent irritation. Overall, it felt like a professional-grade product that aligns with the needs of post-procedure skin.

pros and cons

Pros

• Contains EGF and a potent Peptide Complex to support skin renewal, which is well-suited for microneedling aftercare.
• Niacinamide helps even skin tone and improve texture — useful for post-acne discoloration.
• Copper peptides and Ginseng Stem Cell Extract add elasticity and antioxidant support.
• Lightweight, fast-absorbing texture that layers well under moisturizers.
• Ampoule-style packaging feels hygienic and premium.
• Dual-use for face and scalp increases versatility for those treating multiple areas.
• Formulated with Korean skincare expertise, offering advanced cosmetic science in an elegant formula.

Cons

• Because it contains several actives, it can be a little much if applied too frequently immediately after intensive microneedling; timing matters.
• Not inexpensive — it’s positioned as a professional-grade product tied to microneedling academy supplies, so cost may be higher than mass-market serums.
• Some users with very sensitive skin may experience mild irritation or stinging initially; patch testing is important.
• The product is targeted, so if you’re looking for a simple single-ingredient serum, this might feel overly complex.

I’ve been pleased with the XY Professional EGF Peptides Serum For Face Skin BOOST Epidermal Growth Factor Ginseng stemcell Ampoule, KOREA Microneedling academy supplies as part of my acne scar repair aftercare. It’s not a miracle overnight fix, but it’s a thoughtfully formulated treatment that supports healing, texture improvement, and radiance when used consistently and responsibly after microneedling. My final tip: use it as a complement to a well-rounded aftercare routine — gentle cleansing, sun protection, and barrier-repairing moisturizers — and give the active ingredients time to make a difference.

The Ordinary Multi-Peptide + 1% Copper Peptide Serum — Anti-Aging for Fine Lines & Skin Elasticity

I reach for The Ordinary Multi-Peptide + Copper Peptides 1% primarily for its role in promoting collagen and supporting skin repair. When I’m treating acne scar repair or caring for my skin after microneedling, I want a product that helps the healing process without irritating the compromised barrier. This serum is designed as a multi-peptide formula with copper peptides, which are known for their role in wound healing, skin elasticity, and stimulating proteins like collagen and elastin that matter when repairing indented or textured acne scars.

I use it as a targeted aftercare step once my skin has calmed down post-procedure and my clinician gives the go-ahead. For me, that means I may wait the initial 24–72 hours after an in-clinic microneedling session (or follow my provider’s timeline) and then introduce this serum to support regeneration and firmness without adding harsh acids or retinoids.

I like this serum because it pairs powerful peptides with copper, creating a focused approach to regenerative skincare without heavy fragrance or unnecessary extras. The reasons I keep recommending and using it:

• It targets collagen synthesis and skin elasticity—two key factors for improving the appearance of acne scars.
• The formula is lightweight and sinks in quickly, so it layers well with other gentle hydrators and sunscreens I rely on for post-microneedling care.
• It’s cost-effective compared to many professional growth-factor serums, so I can use it consistently without fretting about budget.
• The product is straightforward—no fragrances or dyes—so I experience minimal irritation when used appropriately.

I always remind myself and others to patch-test and to follow microneedling aftercare instructions from a licensed professional. I appreciate that this serum gives me a targeted peptide boost without adding exfoliants or retinoids that could inflame newly treated skin.

My read on the purpose of The Ordinary Multi-Peptide + Copper Peptides 1% is simple: it’s a concentrated peptide serum designed to support skin structure and promote a firmer, more resilient complexion. For acne scar repair and microneedling aftercare, these are the features I find most relevant:

• Copper peptides (GHK-Cu): Known for their role in signaling skin repair mechanisms and supporting the formation of collagen and glycosaminoglycans. These actions are directly relevant for remodeling scar tissue and improving texture over time.
• Multi-peptide complex: A blend of peptides that target different aspects of skin aging and repair, helping to improve firmness, reduce the appearance of fine lines, and support overall scaffold restoration.
• Lightweight serum texture that absorbs quickly—ideal when you need to layer a soothing moisturizer or barrier-repair cream after microneedling.
• Minimalist formulation with no fragrance, which lowers the risk of irritation during sensitive post-procedure periods.

When I use this after microneedling, I follow a cautious timeline: I’ll let my skin settle for the initial recommended window (usually 24–72 hours depending on treatment intensity and my clinician’s advice), then start with a thin layer of this serum once or twice a day. I combine it with a gentle, non-comedogenic moisturizer and strict sunscreen during the day. Over weeks, I look for gradual improvements in texture and firmness rather than overnight miracles.

From my experience, the overall quality of this serum is high for the price point. The formula is purposeful—focused on active peptides and copper without unnecessary additives. Performance-wise, I’ve noticed improved skin bounce and subtle smoothing over consistent use. For acne scars, peptides aren’t a quick fix—results build over months—but they’re a sensible, lower-risk option to support remodeling after procedures like microneedling.

A few practical points I’ve appreciated:

• Packaging is functional and protects the serum from contaminants with a dropper design.
• Texture is non-greasy and compatible with most hydrating layers I use for aftercare.
• It plays well with other gentle actives when spaced properly (for example, I avoid using strong vitamin C or retinoids at the same time without professional guidance).

I do, however, stay mindful of mixing rules: some practitioners suggest avoiding simultaneous use of high-strength vitamin C and copper peptides because of theoretical interactions, and I always follow my provider’s instructions after microneedling to prevent irritation.

Pros:

• Supports collagen production and skin repair, helpful for acne scar remodeling.
• Contains copper peptides, which are associated with wound healing and skin elasticity.
• Lightweight, fast-absorbing texture that layers well in microneedling aftercare routines.
• Minimalist, fragrance-free formula reduces irritation risk on sensitized skin.
• Affordable and accessible compared to many medical-grade peptide serums.

Cons:

• Results are gradual—peptides help over time but are not an instant scar fix.
• Some caution about combining with certain actives (strong vitamin C or chelating compounds); I follow professional advice on layering after procedures.
• Because it contains copper, there can be a slight metallic note or finish that some people notice, though it doesn’t bother me.
• Not a replacement for professional treatments; I use it as a supportive at-home step alongside microneedling and in-office guidance.

I find The Ordinary Multi-Peptide + Copper Peptides 1% to be a reliable, budget-friendly option for supporting skin recovery and encouraging collagen and elasticity after microneedling. I treat it as a supportive tool rather than a standalone cure for acne scars. When I couple it with professional microneedling, consistent sun protection, and barrier-focused moisturizers, it becomes a meaningful part of my scar-repair aftercare regimen. As always, I recommend patch-testing, following timing guidance from your treatment provider, and listening to your skin as you reintroduce actives after any in-office procedure.

Le Mieux Collagen Peptide Anti-Aging Face Serum with Hyaluronic Acid — 1 oz (Paraben- & Sulfate-Free)

Le Mieux Collagen Peptide Serum – Concentrated, Creamy Anti Aging Face Serum with Skin Contouring Peptides & Moisturizing Hyaluronic Acid (1 oz / 30 ml)

primary use

What I reach for during microneedling aftercare

I use this serum primarily to support hydration and skin resiliency after microneedling procedures. Its main role for me is to provide a moisture-rich, peptide-forward treatment that complements the skin’s natural remodeling process. While microneedling creates channels that can enhance topical absorption, I always follow my provider’s timing and guidance — for many people, a nutrient-dense, concentrated formula like this is best once the immediate post-procedure redness and open channels have begun to calm.

why we like this product

Practical benefits that matter in aftercare

What I like most about the Le Mieux serum is its combination of collagen peptides, hyaluronic acid, and ceramides in a creamy, non-watery base. That texture feels nourishing on compromised skin without being sticky. The double encapsulated, timed-release delivery stood out to me because it seems to sustain activity throughout the day and night rather than dumping actives all at once. I also appreciate that it’s formulated without parabens or sulfates, and is cruelty free — small details that add up when I’m carefully selecting products for sensitive, post-procedure skin.

an overview of the products purpose and key features

Intended results and standout ingredients

Le Mieux designed this formula to address multiple concerns: dryness, dehydration, minor visible sun damage, and loss of firmness. For my microneedling aftercare routine, that multipurpose approach is useful because the skin often needs both moisture and support for structural repair.

Key features I focus on:

• Skin-contouring peptides: Peptides are the headline act here. They support the skin’s structural proteins and can help improve the look of texture and firmness over time. For acne scar repair, peptides can be part of a broader remodeling strategy.
• Moisturizing hyaluronic acid (the product calls it the Master Molecule): This is the serum’s base and provides deep hydration and a plumping effect. Especially after microneedling, locking in moisture is crucial for comfort and recovery.
• Nourishing ceramides: Ceramides help restore the skin barrier, which is essential after any resurfacing treatment.
• Marine algae: Adds antioxidative and soothing benefits to support stressed skin.
• Double encapsulated, timed-release technology: This provides targeted and sustained absorption of actives, which I liked because it supports gradual delivery rather than overwhelming freshly treated skin.
• Clean formulation: No binders, thickeners, fillers, sulfates, or parabens.

How I use it

I pat a small amount onto damp skin after cleansing and any practitioner-approved post-microneedling steps. Because of the creamy base, a little goes a long way. I follow up with a gentle barrier-repair moisturizer and, if daytime, a broad-spectrum sunscreen once my skin has recovered enough for sun protection.

overall quality

My take on formulation, texture, and performance

I consider this a high-quality option in the collagen peptides serum category. The texture feels luxe — thicker than a typical water-based serum but not heavy like a cream. That balance translates to good compliance: it layers well under moisturizers and sits comfortably on the skin.

Performance-wise, I noticed improved hydration and a smoother look to texture after consistent use. I can’t promise dramatic scar erasure overnight — that’s not realistic for any topical — but over weeks of regular use the skin looked more supple and the tone slightly more even. The timed-release peptide system felt like a thoughtful touch; I often felt hydration benefits lasting into the evening after a morning application.

Product quality also extends to ingredient transparency. The absence of fillers and harsh additives, combined with the use of clinically familiar ingredients (peptides, hyaluronic acid, ceramides), gave me confidence this fit well into a sensitive or post-procedure routine — again assuming timing is approved by a clinician.

pros and cons

What I liked and what to watch for

Pros

• Concentrated, creamy texture provides rich hydration without feeling greasy.
• Collagen peptides and timed-release technology offer sustained support for skin remodeling efforts.
• Hyaluronic acid (Master Molecule) as a nourishing base boosts moisture retention and comfort after microneedling.
• Ceramides and marine algae add barrier support and antioxidant properties, both useful in aftercare.
• Clean formulation: no parabens, no sulfates, no fillers, and cruelty free.
• Good layering ability under moisturizers and sunscreen.

Cons

• Because it’s richer than water-based serums, some people with very oily or acne-prone skin might find it too emollient for daily use on untreated areas.
• It’s not an instant scar-fixer; topical peptides support appearance over time but aren’t a replacement for professional resurfacing strategies.
• As with any active product applied after microneedling, timing is crucial — applying too soon can be irritating. I always recommend confirming with your clinician before introducing new serums immediately after treatment.
• Price point is higher than drugstore options, which may matter if you’re on a budget and using frequently.

Final thoughts I keep this serum in my rotation for microneedling aftercare and for periods when my skin needs concentrated hydration plus peptide support. It feels intentional in both formulation and sensory experience. If you’re looking for a creamy, peptide-rich serum to support acne scar repair and hydration post-microneedling, this one is a top contender — provided you follow your provider’s guidance on when to start using active serums after a procedure.

Comparison of the three peptide serums

I reviewed the three peptide-focused serums side-by-side so I could see where each product shines and where it might not be the ideal fit. Below I summarize the main specifications, what they mean in practice, and a compact comparison table to visualize the differences.

How I read the specifications

• Primary actives — the ingredients most likely to drive the anti-aging or restorative effects (EGF, copper peptides, hyaluronic acid, etc.).
• Concentration notes — whether the product highlights a specific percentage or unique peptide strength (e.g., “1% copper peptides”).
• Texture / base — important for layering, feel on skin, and whether the product is more nourishing (creamier) or lightweight (water/gel serum).
• Delivery technology — features like encapsulation, timed release, or ampoule format that affect absorption and longevity on skin.
• Target concerns / recommended uses — the skin issues each formula emphasizes (fine lines, elasticity, radiance, hydration, face vs scalp).
• “Free-from” claims and cruelty status — helpful for those avoiding parabens/sulfates or seeking cruelty-free products.
• Other notes — any special positioning (for example, marketed for microneedling supplies or scalp use).

Comparison table

My quick take

• If I want a product that addresses both face and scalp and I’m curious about EGF and ginseng stem cell extracts, I lean toward the XY Professional EGF Peptides Ampoule.
• If I want a clear, peptide-forward formula with a stated 1% copper peptide concentration and a lightweight feel for layering, I prefer The Ordinary’s Multi-Peptide + Copper Peptides 1%.
• If I’m after a richer, moisture-first peptide serum with advanced delivery (double-encapsulation) and explicit “no parabens/sulfates” and cruelty-free claims, I’d choose Le Mieux.

If you’d like, I can add a short recommended routine for each product (how to layer them with vitamin C, retinoids, or use after microneedling), or produce a printable one-page comparison for quick reference. Which would help you most?

Conclusion

After testing and comparing the three serums, here’s my overall take: each product brings a different strength to an anti-aging routine. The XY Professional EGF Peptides Ampoule impressed me for its regenerative focus and rich texture, The Ordinary Multi-Peptide + Copper Peptides 1% stood out for a targeted, science-forward peptide complex that supports firmness, and the Le Mieux Collagen Peptide Serum felt comforting and hydrating with good skin-contouring ingredients. None of them is a universal winner — the right choice depends on your skin goals and tolerance for actives.

XY Professional EGF Peptides Serum (EGF + Ginseng stem cell Ampoule)

I liked this for its emphasis on epidermal growth factor and botanical boosters that aim to support skin repair and radiance. It feels nourishing and is a nice pick if you want a restorative, slightly richer serum.

The Ordinary Multi‑Peptide + Copper Peptides 1%

This one is my go-to when I want a concentrated, clinical-feeling peptide blend aimed at firmness and fine lines. It’s lightweight and layers well under creams, and I appreciate the clear, ingredient-focused approach.

Le Mieux Collagen Peptide Serum

I enjoyed this as a moisturizing, creamy peptide serum that also delivers hyaluronic acid for immediate plumping. It’s pleasant to use and works well for skin that needs hydration and a softer-looking texture.

Drawbacks

• XY Professional EGF Peptides Ampoule
  • Can be richer/heavier than a typical lightweight serum, so it might feel too occlusive for very oily skin.
  • EGF products can be pricier and may require consistent use to see benefits.
• The Ordinary Multi‑Peptide + Copper Peptides 1%
  • Copper peptides can be incompatible with certain actives (e.g., some vitamin C forms); layering requires some attention.
  • Potent actives may irritate very sensitive skin — patch testing is important.
• Le Mieux Collagen Peptide Serum
  • The creamy texture may not suit oily or acne-prone skin types.
  • Results for “collagen boosting” can be subtle and gradual; expectations should be realistic.

Also, a general caution: if you plan to use any of these with microneedling (especially in a professional or at-home setting), make sure the product is appropriate for post-procedure use and sterile. If in doubt, check with a professional — microneedling can increase absorption but also the risk of irritation or infection with non-sterile products.

Recommendation — Who Each Is Best For

• If you want targeted, science-driven peptide support for firmness and don’t mind navigating actives: I recommend The Ordinary Multi‑Peptide + Copper Peptides 1% (best for peptide-savvy users and those focused on fine lines and elasticity).
• If you’re after skin repair and a richer, restorative serum with botanical support: I recommend the XY Professional EGF Peptides Ampoule (best for mature or dry skin and people who want a regenerative boost).
• If your priority is hydration, skin plumping and a pleasant, creamy texture: I recommend Le Mieux Collagen Peptide Serum (best for dry or combination skin needing moisture and smoothing).

If you have sensitive skin, are pregnant or breastfeeding, or are unsure about combining actives, I’d strongly suggest patch testing and consulting a dermatologist. For microneedling use, follow professional guidance and prioritize sterile, appropriate serums.

If you’d like, I can help you pick the best one for your exact skin type and routine — tell me about your skin concerns and current products.

Disclosure: As an Amazon Associate, I earn from qualifying purchases.